Ralf Rangnick, 63, will need to leave his position as head of sports and development at Lokomotiv Moscow to take up the role; Michael Carrick has been placed in temporary charge while United conduct a thorough process to appoint an interim boss.
Ralf Rangnick is close to finalising a deal to become Manchester United interim manager until the end of the season.
Discussions are ongoing over a deal that would also see Rangnick remain at the club for two years beyond the end of the season in a consultancy role.
Rangnick, 63, is currently manager of sports and development for Lokomotiv Moscow and United remain in talks with the Russian club over an agreement to release him.
As it stands, Michael Carrick is still expected to be in charge for Sunday’s Premier League game at Chelsea.
Carrick has been placed in temporary charge while United conduct a thorough process to appoint an interim boss following the sacking of Ole Gunnar Solskjaer last week.
Former Barcelona head coach Ernesto Valverde and former Lyon head coach Rudi Garcia had also been considered for the interim role
The club are planning to make a permanent appointment at the end of the season and Paris Saint-Germain boss Mauricio Pochettino is their first choice, with Ajax head coach Erik ten Hag also in their thinking.
Before this development, Roberto Mancini had reportedly made a decision on Manchester United job after being contacted to take over in summer as replacement for Ole Gunnar Solskjaer.
Mancini had told Manchester United he is not prepared to leave his job as Italy head coach to become manager at Old Trafford.
Ole Gunnar Solskjaer was relieved of his duties on Sunday in the wake of United’s dismal 4-1 defeat to Watford, with the club suffering seven losses in 13 games under the Norwegian.